Recent advances in biomedical applications of accelerator mass spectrometry
نویسندگان
چکیده
منابع مشابه
Biomedical accelerator mass spectrometry: recent applications in metabolism and pharmacokinetics.
BACKGROUND Accelerator mass spectrometry (AMS) is a sensitive isotope ratio technique used in drug development that allows for small levels of 14C-drug to be administered to humans, thereby removing regulatory hurdles associated with radiotracer studies. AMS uses innovative study designs to obtain pharmacokinetic and metabolism data. OBJECTIVE This review addresses the metabolism and pharmaco...
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Accelerator mass spectrometry (AMS) is the most sensitive method for detecting and quantifying rare long-lived isotopes with high precision. In this chapter, we review the principles underlying AMS-based biomedical studies, focusing on important practical considerations and experimental procedures needed for the detection and quantitation of (14)C- and (3)H-labeled compounds in various experime...
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متن کاملAccelerator mass spectrometry and its applications
The state of the art in accelerator mass spectrometry (AMS) is reviewed. The review is divided in two parts. The first covers the general methodology, followed by its specific elaborations for the commonly measured long-lived isotopes such as 10Be, 14C, 26Al, 36Cl and 129I, as well as other isotopes with emerging applications. The second part considers the very wide spectrum of applications tha...
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ژورنال
عنوان ژورنال: Journal of Biomedical Science
سال: 2009
ISSN: 1423-0127
DOI: 10.1186/1423-0127-16-111